A virus with DNA fragments were injected into the blood of the animal that produced high levels of antibodies that destroy the tumor
ADVANCE. After this successful experiment, the scientists plan to attack the first tests for the disease in humans (Foto: Archivo EL UNIVERSAL )
ADVANCE. After this successful experiment, the scientists plan to attack the first tests for the disease in humans (Foto: Archivo EL UNIVERSAL )
An important progress in the creation of genetic vaccines conducted by researchers at the University of Leeds, UK, and of the Mayo Clinic in Rochester, United States.
This is the use of a virus containing DNA fragments that are the cause of prostate cancer, which when injected in the blood of diseased mice produce large amounts of antibodies that end up destroying the tumor. The hopeful results are published in the latest edition of Nature Medicine.
Until now, researchers feared that a vaccine with several genes could cause a real explosion immune system, which could get out of control and cause death.
So they were surprised to see that the current vaccine works smoothly and has the desired effects are to destroy malignant cells.
The next step is to test its efficacy in humansAfter this successful experiment, the scientists plan to design several other vaccines that target specific tumors in various organs.
You only need to be identified genes in each tumor malignant, place in a special virus and inject millions of these viruses in the patient's blood to cause the destruction of cancer.
As several genes used, several attack routes that open into the tumor, which ensures the success of this therapy.
"This is the first time we succeed by using various genes in a vaccine, without damaging any other organ, except that is affected by the tumor," says Dr. Alan Melcher of the University of Leeds and co-author of the study.
To have these results, the key was that all the genes were specific to the prostate.
For Professor Peter Johnson, head of the Center for Clinical Cancer Research UK, this is an interesting study that could expand the use of vaccines to treat various tumors.
This is the use of a virus containing DNA fragments that are the cause of prostate cancer, which when injected in the blood of diseased mice produce large amounts of antibodies that end up destroying the tumor. The hopeful results are published in the latest edition of Nature Medicine.
Until now, researchers feared that a vaccine with several genes could cause a real explosion immune system, which could get out of control and cause death.
So they were surprised to see that the current vaccine works smoothly and has the desired effects are to destroy malignant cells.
The next step is to test its efficacy in humansAfter this successful experiment, the scientists plan to design several other vaccines that target specific tumors in various organs.
You only need to be identified genes in each tumor malignant, place in a special virus and inject millions of these viruses in the patient's blood to cause the destruction of cancer.
As several genes used, several attack routes that open into the tumor, which ensures the success of this therapy.
"This is the first time we succeed by using various genes in a vaccine, without damaging any other organ, except that is affected by the tumor," says Dr. Alan Melcher of the University of Leeds and co-author of the study.
To have these results, the key was that all the genes were specific to the prostate.
For Professor Peter Johnson, head of the Center for Clinical Cancer Research UK, this is an interesting study that could expand the use of vaccines to treat various tumors.
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